Regulation of Blood Coagulation by the Protein C Anticoagulant Pathway
نویسندگان
چکیده
منابع مشابه
Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition.
The protein C system provides important control of blood coagulation by regulating the activities of factor VIIIa (FVIIIa) and factor Va (FVa), cofactors in the activation of factor X and prothrombin, respectively. The system comprises membrane-bound and circulating proteins that assemble into multi-molecular complexes on cell surfaces. Vitamin K-dependent protein C, the key component of the sy...
متن کاملRegulation and functions of the protein C anticoagulant pathway.
The protein C pathway plays a critical role in the negative regulation of the blood clotting process. We recently identified an endothelial cell receptor for protein C/activated protein C (APC). The receptor is localized almost exclusively on endothelial cells of large vessels and is present at only trace levels or indeed absent from capillaries in most tissues. Patients with sepsis or lupus er...
متن کاملThe anticoagulant protein C pathway.
The anticoagulant protein C system regulates the activity of coagulation factors VIIIa and Va, cofactors in the activation of factor X and prothrombin, respectively. Protein C is activated on endothelium by the thrombin-thrombomodulin-EPCR (endothelial protein C receptor) complex. Activated protein C (APC)-mediated cleavages of factors VIIIa and Va occur on negatively charged phospholipid membr...
متن کاملThe protein C anticoagulant pathway.
Although protein C was described as an anticoagulant in 1960 by Dr. Seegers and colleagues, widespread appreciation of the complexity of its activation, function, and physiological roles did not begin to develop until Stenflo independently characterized protein C as a vitamin K-dependent zymogen that could be converted to a serine protease capable of membrane binding (Esmon et al). The subseque...
متن کاملBlood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis of bleeding and thrombotic diseases.
Blood coagulation and its regulation by anticoagulant pathways: genetic pathogenesis Platelet-mediated primary haemostasis and blood coagulation have evolved as important defence mechanisms against bleeding. The formation of the platelet plug provides the initial occlusion of the vascular lesion. This is temporally co-ordinated with the activation of the coagulation system, which occurs in resp...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2005
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000168421.13467.82